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L 006235
CAS No. 294623-49-7
L 006235( —— )
Catalog No. M22746 CAS No. 294623-49-7
L 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
|
| 5MG | 87 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 295 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 718 | In Stock |
|
| 500MG | 1485 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL 006235
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NoteResearch use only, not for human use.
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Brief DescriptionL 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
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DescriptionL 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
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In Vitro——
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In VivoAnimal Model:Rhesus monkey (15 years) receiving oophorectomy (OVX)Dosage:0.6, 3, 15 mg/kg Administration:P.o once daily for 8-11 days Result:Decreased uNTx/Cre by an average of 76%, 68%, and 31% at the dose of 15, 3, and 0.6 mg/kg, respectively.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetCysteine Protease
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Recptorcathepsin K
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Research Area——
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Indication——
Chemical Information
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CAS Number294623-49-7
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Formula Weight466.6
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Molecular FormulaC24H30N6O2S
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Purity>98% (HPLC)
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SolubilityDMSO:42mg/ml
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SMILESCN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lena Svelande , Helena Erlandsson-Harris, Leif Astner, et al.Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.Eur J Pharmacol. 2009 Jun 24;613(1-3):155-62.
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